Publications

2011

Dibaj P, Steffens H, Zschuntzsch J, Nadrigny F, Schomburg ED, Kirchhoff F, Neusch C (2011) In Vivo Imaging Reveals Distinct Inflammatory Activity of CNS Microglia versus PNS Macrophages in a Mouse Model for ALS. Plos One 6:e17910.

Perez-Cruz C, Nolte MW, van Gaalen MM, Rustay NR, Termont A, Tanghe A, Kirchhoff F, Ebert U (2011) Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease. J Neurosci 31:3926-3934.

Dibaj P, Steffens H, Nadrigny F, Kirchhoff F, Schomburg ED (2011) Purinergic activation of dorsal root ganglion neurones in vivo. Neurosci Lett 487:107-109.

2010

Beckervordersandforth R, Tripathi P, Ninkovic J, Bayam E, Lepier A, Stempfhuber B, Kirchhoff F, Hirrlinger J, Haslinger A, Lie DC, Beckers J, Yoder B, Irmler M, Gotz M (2010) In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell 7:744-758.

Dibaj P, Steffens H, Nadrigny F, Neusch C, Kirchhoff F, Schomburg ED (2010) Long-lasting post-mortem activity of spinal microglia in situ in mice. J Neurosci Res 88:2431-2440.

Dibaj P, Nadrigny F, Steffens H, Scheller A, Hirrlinger J, Schomburg ED, Neusch C, Kirchhoff F (2010) NO mediates microglial response to acute spinal cord injury under ATP control in vivo. Glia 58:1133-1144.

Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP (2010) Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A 107:6058-6063.

Kirchhoff F (2010) Questionable Calcium. Science 327:1212-1213.

Reichenbach A, Derouiche A, Kirchhoff F (2010) Morphology and dynamics of perisynaptic glia. Brain Res Rev 63:11-25.

2009

Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner MJ, Kirchhoff F (2009) Split-cre complementation indicates coincident activity of different genes in vivo. Plos One 4:e4286.

Neher RA, Mitkovski M, Kirchhoff F, Neher E, Theis FJ, Zeug A (2009) Blind source separation techniques for the decomposition of multiply labeled fluorescence images. Biophys J 96:3791-3800.

Ylera B, Erturk A, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F (2009) Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon. Curr Biol 19:930-936.

2008

Dimou L, Simon C, Kirchhoff F, Takebayashi H, Gotz M (2008) Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28:10434-10442.

Hamilton N, Vayro S, Kirchhoff F, Verkhratsky A, Robbins J, Gorecki DC, Butt AM (2008) Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes. Glia 56:734-749.

Lalo U, Pankratov Y, Wichert SP, Rossner MJ, North RA, Kirchhoff F, Verkhratsky A (2008) P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes. J Neurosci 28:5473-5480.

Wolf F, Kirchhoff F (2008) Neuroscience - Imaging astrocyte activity. Science 320:1597-1599.

2007

Chvatal A, Anderova M, Hock M, Prajerova I, Neprasova H, Chvatal V, Kirchhoff F, Sykova E (2007) Three-dimensional confocal morphometry reveals structural changes in astrocyte morphology in situ. J Neurosci Res 85:260-271.

Chvatal A, Anderova M, Kirchhoff F (2007) Three-dimensional confocal morphometry - a new approach for studying dynamic changes in cell morphology in brain slices. J Anat 210:671-683.

Dibaj P, Kaiser M, Hirrlinger J, Kirchhoff F, Neusch C (2007) Kir4.1 channels regulate swelling of astroglial processes in experimental spinal cord edema. J Neurochem.

Giaume C, Kirchhoff F, Matute C, Reichenbach A, Verkhratsky A (2007) Glia: the fulcrum of brain diseases. Cell Death Differ 14:1324-1335.

Nadrigny F, Li D, Kemnitz K, Ropert N, Koulakoff A, Rudolph S, Vitali M, Giaume C, Kirchhoff F, Oheim M (2007) Systematic colocalization errors between acridine orange and EGFP in astrocyte vesicular organelles. Biophys J 93:969-980.

Oertel J, Villmann C, Kettenmann H, Kirchhoff F, Becker CM (2007) A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes. J Biol Chem 282:2798-2807.

Verkhratsky A, Kirchhoff F (2007) Glutamate-mediated neuronal-glial transmission. J Anat 210:651-660.

Verkhratsky A, Kirchhoff F (2007) NMDA Receptors in glia. Neuroscientist 13:28-37.

Wigley R, Hamilton N, Nishiyama A, Kirchhoff F, Butt AM (2007) Morphological and physiological interactions of NG2-glia with astrocytes and neurons. J Anat 210:661-670.

Winter SM, Hirrlinger J, Kirchhoff F, Hulsmann S (2007) Transgenic expression of fluorescent proteins in respiratory neurons. Respir Physiol Neurobiol 159:108-114.

Wu Q, Butzkueven H, Gresle M, Kirchhoff F, Friedhuber A, Yang Q, Wang H, Fang K, Lei H, Egan GF, Kilpatrick TJ (2007) MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve. Neuroimage 37:1138-1147.

2006

Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R (2006) Exosomes are released by cultured cortical neurones. Mol Cell Neurosci 31:642-648.

Hirrlinger PG, Scheller A, Braun C, Hirrlinger J, Kirchhoff F (2006) Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2. Glia 54:11-20.

Houades V, Rouach N, Ezan P, Kirchhoff F, Koulakoff A, Giaume C (2006) Shapes of astrocyte networks in the juvenile brain. Neuron Glia Biol 2:3-14.

Kaiser M, Maletzki I, Hulsmann S, Holtmann B, Schulz-Schaeffer W, Kirchhoff F, Bahr M, Neusch C (2006) Progressive loss of a glial potassium channel (KCNJ10) in the spinal cord of the SOD1 (G93A) transgenic mouse model of amyotrophic lateral sclerosis. J Neurochem 99:900-912.

Lalo U, Pankratov Y, Kirchhoff F, North RA, Verkhratsky A (2006) NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes. J Neurosci 26:2673-2683.

Lu YB, Franze K, Seifert G, Steinhauser C, Kirchhoff F, Wolburg H, Guck J, Janmey P, Wei EQ, Kas J, Reichenbach A (2006) Viscoelastic properties of individual glial cells and neurons in the CNS. Proc Natl Acad Sci U S A 103:17759-17764.

Nadrigny F, Rivals I, Hirrlinger PG, Koulakoff A, Personnaz L, Vernet M, Allioux M, Chaumeil M, Ropert N, Giaume C, Kirchhoff F, Oheim M (2006) Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing. Eur Biophys J 35:533-547.

Neusch C, Papadopoulos N, Muller M, Maletzki I, Winter SM, Hirrlinger J, Handschuh M, Bahr M, Richter DW, Kirchhoff F, Hulsmann S (2006) Lack of the Kir4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation. J Neurophysiol 95:1843-1852.

Oheim M, Kirchhoff F, Stuhmer W (2006) Calcium microdomains in regulated exocytosis. Cell Calcium 40:423-439.

2005

Hirrlinger J, Moeller H, Kirchhoff F, Dringen R (2005) Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell RT-PCR study. Neurochem Res 30:1237-1244.

Hirrlinger PG, Scheller A, Braun C, Quintela-Schneider M, Fuss B, Hirrlinger J, Kirchhoff F (2005) Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice. Mol Cell Neurosci 30:291-303.

Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318.

2004

Grass D, Pawlowski PG, Hirrlinger J, Papadopoulos N, Richter DW, Kirchhoff F, Hulsmann S (2004) Diversity of functional astroglial properties in the respiratory network. J Neurosci 24:1358-1365.

Hirrlinger J, Hulsmann S, Kirchhoff F (2004) Astroglial processes show spontaneous motility at active synaptic terminals in situ. Eur J Neurosci 20:2235-2239.

Nimmerjahn A, Kirchhoff F, Kerr JN, Helmchen F (2004) Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nat Methods 1:31-37.

2003

Huttmann K, Sadgrove M, Wallraff A, Hinterkeuser S, Kirchhoff F, Steinhauser C, Gray WP (2003) Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis. Eur J Neurosci 18:2769-2778.

Malatesta P, Hack MA, Hartfuss E, Kettenmann H, Klinkert W, Kirchhoff F, Gotz M (2003) Neuronal or glial progeny: regional differences in radial glia fate. Neuron 37:751-764.

Matthias K, Kirchhoff F, Seifert G, Huttmann K, Matyash M, Kettenmann H, Steinhauser C (2003) Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus. J Neurosci 23:1750-1758.

Wehner T, Bontert M, Eyupoglu I, Prass K, Prinz M, Klett FF, Heinze M, Bechmann I, Nitsch R, Kirchhoff F, Kettenmann H, Dirnagl U, Priller J (2003) Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. J Neurosci 23:5004-5011.

2002

Schipke CG, Boucsein C, Ohlemeyer C, Kirchhoff F, Kettenmann H (2002) Astrocyte Ca2+ waves trigger responses in microglial cells in brain slices. FASEB J 16:255-257.

2001

Diers-Fenger M, Kirchhoff F, Kettenmann H, Levine JM, Trotter J (2001) AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia. Glia 34:213-228.

Kirchhoff F, Dringen R, Giaume C (2001) Pathways of neuron-astrocyte interactions and their possible role in neuroprotection. Eur Arch Psychiatry Clin Neurosci 251:159-169.

Nolte C, Matyash M, Pivneva T, Schipke CG, Ohlemeyer C, Hanisch UK, Kirchhoff F, Kettenmann H (2001) GFAP promoter-controlled EGFP-expressing transgenic mice: a tool to visualize astrocytes and astrogliosis in living brain tissue. Glia 33:72-86.

Schipke CG, Ohlemeyer C, Matyash M, Nolte C, Kettenmann H, Kirchhoff F (2001) Astrocytes of the mouse neocortex express functional N-methyl-D-aspartate receptors. FASEB J 15:1270-1272.

Synowitz M, Ahmann P, Matyash M, Kuhn SA, Hofmann B, Zimmer C, Kirchhoff F, Kiwit JC, Kettenmann H (2001) GABA(A)-receptor expression in glioma cells is triggered by contact with neuronal cells. Eur J Neurosci 14:1294-1302.

2000

Fuss B, Mallon B, Phan T, Ohlemeyer C, Kirchhoff F, Nishiyama A, Macklin WB (2000) Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein. Dev Biol 218:259-274.

1999

Condorelli DF, Conti F, Gallo V, Kirchhoff F, Seifert G, Steinhauser C, Verkhratsky A, Yuan X (1999) Expression and functional analysis of glutamate receptors in glial cells. Adv Exp Med Biol 468:49-67.

Kirischuk S, Kirchhoff F, Matyash V, Kettenmann H, Verkhratsky A (1999) Glutamate-triggered calcium signalling in mouse bergmann glial cells in situ: role of inositol-1,4,5-trisphosphate-mediated intracellular calcium release. Neuroscience 92:1051-1059.

Schmidt K, Eulitz D, Veh RW, Kettenmann H, Kirchhoff F (1999) Heterogeneous expression of voltage-gated potassium channels of the shaker family (Kv1) in oligodendrocyte progenitors. Brain Res 843:145-160.

1998

Prinz M, Hanisch UK, Kettenmann H, Kirchhoff F (1998) Alternative splicing of mouse IL-15 is due to the use of an internal splice site in exon 5. Brain Res Mol Brain Res 63:155-162.

Schmidt-Ott KM, Tuschick S, Kirchhoff F, Verkhratsky A, Liefeldt L, Kettenmann H, Paul M (1998) Single-cell characterization of endothelin system gene expression in the cerebellum in situ. J Cardiovasc Pharmacol 31 Suppl 1:S364-S366.

1997

Hanisch UK, Lyons SA, Prinz M, Nolte C, Weber JR, Kettenmann H, Kirchhoff F (1997) Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity. J Biol Chem 272:28853-28860.

Kirchhoff F, Ohlemeyer C, Kettenmann H (1997) Expression of myelin-associated glycoprotein transcripts in murine oligodendrocytes. Neuroscience 78:561-570.

Moller T, Kann O, Prinz M, Kirchhoff F, Verkhratsky A, Kettenmann H (1997) Endothelin-induced calcium signaling in cultured mouse microglial cells is mediated through ETB receptors. Neuroreport 8:2127-2131.

Nolte C, Kirchhoff F, Kettenmann H (1997) Epidermal growth factor is a motility factor for microglial cells in vitro: evidence for EGF receptor expression. Eur J Neurosci 9:1690-1698.

Terness P, Welschof M, Moldenhauer G, Jung M, Moroder L, Kirchhoff F, Kipriyanov S, Little M, Opelz G (1997) Idiotypic vaccine for treatment of human B-cell lymphoma. Construction of IgG variable regions from single malignant B cells. Hum Immunol 56:17-27.

Tuschick S, Kirischuk S, Kirchhoff F, Liefeldt L, Paul M, Verkhratsky A, Kettenmann H (1997) Bergmann glial cells in situ express endothelinB receptors linked to cytoplasmic calcium signals. Cell Calcium 21:409-419.

1996

Kirchhoff F, Mulhardt C, Pastor A, Becker CM, Kettenmann H (1996) Expression of glycine receptor subunits in glial cells of the rat spinal cord. J Neurochem 66:1383-1390.

1994

Jabs R, Kirchhoff F, Kettenmann H, Steinhauser C (1994) Kainate activates Ca(2+)-permeable glutamate receptors and blocks voltage-gated K+ currents in glial cells of mouse hippocampal slices. Pflugers Arch 426:310-319.

1993

Fahrig T, Probstmeier R, Spiess E, Meyer-Franke A, Kirchhoff F, Drescher B, Schachner M (1993) Functional topography of the myelin-associated glycoprotein. I. Mapping of domains by electron microscopy. Eur J Neurosci 5:1118-1126.

Gimpl G, Kirchhoff F, Lang RE, Kettenmann H (1993) Identification of neuropeptide Y receptors in cultured astrocytes from neonatal rat brain. J Neurosci Res 34:198-205.

Kirchhoff F, Hofer HW, Schachner M (1993) Myelin-associated glycoprotein is phosphorylated by protein kinase C. J Neurosci Res 36:368-381.

1992

Kirchhoff F, Ohlemeyer C, Kettenmann H (1992) A fast perfusion system for single cell physiology optimized for microscopes with water immersion objectives. Pflugers Arch 420:573-577.

Kirchhoff F, Kettenmann H (1992) GABA Triggers a [Ca2+]i Increase in Murine Precursor Cells of the Oligodendrocyte Lineage. Eur J Neurosci 4:1049-1058.

1991

Schneider-Schaulies J, Kirchhoff F, Archelos J, Schachner M (1991) Down-regulation of myelin-associated glycoprotein on Schwann cells by interferon-gamma and tumor necrosis factor-alpha affects neurite outgrowth. Neuron 7:995-1005.

1990

Bartsch U, Kirchhoff F, Schachner M (1990) Highly sialylated N-CAM is expressed in adult mouse optic nerve and retina. J Neurocytol 19:550-565.

1989

Bartsch U, Kirchhoff F, Schachner M (1989) Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice. J Comp Neurol 284:451-462.

Sadoul R, Kirchhoff F, Schachner M (1989) A protein kinase activity is associated with and specifically phosphorylates the neural cell adhesion molecule L1. J Neurochem 53:1471-1478.